One Slice of Lust is a parody game based on the One-Piece anime story. The story revolves around the StrawHat Pirates who are targeted by one of the great emperors, Marshall D. Teach that makes them more desperate to meet their sexual needs that they never had before. Luffy who is captain of the Straw Hats will be the first target and the most affected of all. Zoro, Usopp, Nami, Sanji, Robin, Franky, Brook and their friends are not so affected but will follow their captain's wishes​